HCID 12545264、化合物 → N~1~-([1,1'-Biphenyl]-2-yl)benzene-1,2-diamine

HRID 383214ノート

反応式

HRID 383214 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11]1[C:12]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:13][CH:14]=[CH:15][CH:16]=1)([O-])=O.[H][H]>[Pd].C(O)C>[C:12]1([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[NH:10][C:5]1[C:4]([NH2:1])=[CH:9][CH:8]=[CH:7][CH:6]=1

参加物

5

反応物 2

HCID 12545264HCID 12545264、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 13989156N~1~-([1,1'-Biphenyl]-2-yl)benzene-1,2-diamine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

N-(2-nitrophenyl)biphenyl-2-amine (19.69 g, 67.8 mmol), 10% palladium on carbon (0.29 g, 0.27 mmol), and 150 mL of ethanol was added to a Parr hydrogenator bottle. The mixture was hydrogenated on a Parr hydrogenator until no more hydrogen was taken up by the solution. The solution was filtered through Celite to remove the catalyst, Celite was washed with dichloromethane, the filtrate was evaporated to yield a brown oil, 14.8 g (84%). The product was used for the next step without further purification.

後処理

  1. filtrationThe solution was filtered through Celite
  2. customto remove the catalyst, Celite
  3. washwas washed with dichloromethane
  4. customthe filtrate was evaporated
  5. customto yield a brown oil, 14.8 g (84%)
  6. customThe product was used for the next step without further purification

出典と根拠

ORDレコード
ord-8fa2ac664396495a8847c2a25ca89096
出典データセット
uspto-grants-2013_02
特許番号
US08367223B2

反応ノート

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