反応式
[CH:1]([C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][N:10]=1)[C:6]#[N:7])=[CH2:2].[CH3:11][N:12]([CH3:30])[C:13]([C:15]1[O:16][C:17]2[C:23]([N:24]3[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]3)=[CH:22][CH:21]=[CH:20][C:18]=2[CH:19]=1)=[O:14].C(O)(=O)C>C(O)C>[C:6]([C:5]1[CH:8]=[CH:9][N:10]=[C:3]([CH2:1][CH2:2][N:27]2[CH2:28][CH2:29][N:24]([C:23]3[C:17]4[O:16][C:15]([C:13]([N:12]([CH3:30])[CH3:11])=[O:14])=[CH:19][C:18]=4[CH:20]=[CH:21][CH:22]=3)[CH2:25][CH2:26]2)[CH:4]=1)#[N:7]参加物
5
反応条件
- 温度
- 90 °C
実験手順
The compound was prepared according to the procedure disclosed in Example 39 starting from of 2-vinylisonicotinonitrile (0.076 g, 0.59 mmol), N,N-dimethyl-7-(piperazin-1-yl)benzofuran-2-carboxamide (0.080 g, 0.29 mmol) (Example 39d), and acetic acid (0.013 mL, 0.23 mmol). Ethanol was used as solvent and the reaction heated at 90° C. for two days. The crude product was purified by preparative HPLC to give the title compound.
後処理
- customThe compound was prepared
- customThe crude product was purified by preparative HPLC
出典と根拠
- ORDレコード
- ord-51688835e6bf46c0b7feffc884d64030
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08367676B2
関連ノート
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