化工社化工社 化学情報印刷レポート · 研究参考用
HRID 383832作成日：2026年10月26日
Acetic Acid → Azetidin-1-yl(7-(4-(2-(6-methoxypyridin-2-yl)ethyl)piperazin-1-yl)benzofuran-2-yl)methanone
https://huagongshe.com/reaction/383832
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | 2-Methoxy-6-vinylpyridine | HCID 19091566 | — |
| 反応物 | Azetidin-1-yl(7-(piperazin-1-yl)benzofuran-2-yl)methanone | HCID 59636763 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Azetidin-1-yl(7-(4-(2-(6-methoxypyridin-2-yl)ethyl)piperazin-1-yl)benzofuran-2-yl)methanone | HCID 59636730 | — |
反応手順
Azetidin-1-yl(7-(piperazin-1-yl)benzofuran-2-yl)methanone (0.070 g, 0.25 mmol) was dissolved in methanol (1 mL). 2-Methoxy-6-vinylpyridine (0.066 g, 0.49 mmol) and acetic acid (0.014 mL, 0.25 mmol) were added. The mixture was heated by microwave irradiation to 120° C. for 10 h. The product was purified by preparative HPLC to give the title compound. Yield: 0.044 g (43%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08367676B2 |
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| 出典データセット | uspto-grants-2013_02 |
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| ORD ID | ord-6cde1129c98247938e4fea1f5bc2e6f2 |
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| 出典メモ | uspto-grants-2013_02 |
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