Hydrochloric Acid → HCID 21651637、化合物

HRID 383912

反応式

HRID 383912 の反応式
[Cl:1][C:2]1[S:3][C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[C:5]([C:7]([O:9]CC)=[O:8])[N:6]=1.[OH-].[K+].Cl>C1COCC1>[Cl:1][C:2]1[S:3][C:4]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)=[C:5]([C:7]([OH:9])=[O:8])[N:6]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 59291332Ethyl 2-chloro-5-phenylthiazole-4-carboxylate

生成物 1

HCID 21651637HCID 21651637、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
60 °C

実験手順

To a solution of ethyl 2-chloro-5-phenylthiazole-4-carboxylate in THF was added a 1 M aqueous KOH solution, followed by stirring at 60° C. for 30 minutes. To the reaction mixture was added 1 M hydrochloric acid, and the solid precipitated was collected by filtration to obtain 2-chloro-5-phenylthiazole-4-carboxylic acid as a white solid.

後処理

  1. customthe solid precipitated
  2. filtrationwas collected by filtration

出典と根拠

ORDレコード
ord-04fa5b16812c41a681063f426068f445
出典データセット
uspto-grants-2013_02
特許番号
US08367696B2

関連ノート

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