Water → 3-Phenoxy-benzeneethanol

HRID 384130

反応式

HRID 384130 の反応式
[O:1]([C:8]1[CH:9]=[C:10]([CH2:14][C:15](O)=[O:16])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O>O1CCCC1.B.O1CCCC1>[O:1]([C:8]1[CH:9]=[C:10]([CH2:14][CH2:15][OH:16])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 962WaterHCID 1417493-Phenoxyphenylacetic acid

生成物 1

HCID 139291293-Phenoxy-benzeneethanol

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒HCID 2723981Borane;tetrahydrofuran溶媒

実験手順

To a solution of (3-phenoxyphenyl)acetic acid (1.157 g) in tetrahydrofuran (23 ml), 6.5 ml of borane-tetrahydrofuran complex (1.17M tetrahydrofuran solution) was added, and the reaction solution was stirred at room temperature for 2 hours. To the reaction solution was added water, and the mixture was extracted with chloroform and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the residue obtained was purified by silica gel column chromatography (eluent: ethyl acetate/hexane (10:90-80/20)) to afford the title compound as a colorless oil.

後処理

  1. extractionthe mixture was extracted with chloroform
  2. dry with materialdried over anhydrous sodium sulfate
  3. distillationThe solvent was distilled off under reduced pressure
  4. customthe residue obtained
  5. customwas purified by silica gel column chromatography (eluent: ethyl acetate/hexane (10:90-80/20))

出典と根拠

ORDレコード
ord-41d8072ff54f4585ac33d72cb7cc8a8f
出典データセット
uspto-grants-2013_02
特許番号
US08367708B2

関連ノート

読み込み中…