Hydrogen Bromide → HCID 136117081、化合物
反応式
C[O:2][C:3]1[C:8]([NH2:9])=[CH:7][CH:6]=[CH:5][C:4]=1[C:10]1[S:11][C:12]([CH3:18])=[C:13]([C:15]([OH:17])=[O:16])[N:14]=1.[BrH:19]>>[BrH:19].[OH:2][C:3]1[C:8]([NH2:9])=[CH:7][CH:6]=[CH:5][C:4]=1[C:10]1[S:11][C:12]([CH3:18])=[C:13]([C:15]([OH:17])=[O:16])[N:14]=1参加物
3
反応条件
- 温度
- 80 °C
実験手順
2-(2-Methoxy-3-amino-phenyl)-5-methyl-thiazole-4-carboxylic acid 47b (280 mg, 0.94 mmol) was dissolved in 5 mL of hydrogen bromide. The reaction mixture was stirred overnight at 80° C. The reaction was monitored by TLC until the disappearance of the starting materials. The mixture was filtered and the filter cake was washed with ethyl acetate and dried to obtain the title compound 2-(2-hydroxy-3-amino-phenyl)-5-methyl-thiazole-4-carboxylic acid hydrobromide 47c (200 mg, yield 64%) as a yellow solid.
後処理
- filtrationThe mixture was filtered
- washthe filter cake was washed with ethyl acetate