Hydrogen Bromide → (S)-methyl 2-amino-4,4-difluoro-5-phenylpentanoate hydrobromide

反応式

C(OC([NH:11][C@@H:12]([CH2:17][C:18]([F:27])([F:26])[CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:13]([O:15][CH3:16])=[O:14])=O)C1C=CC=CC=1.[BrH:28]>>[BrH:28].[NH2:11][C@@H:12]([CH2:17][C:18]([F:26])([F:27])[CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:13]([O:15][CH3:16])=[O:14]

参加物

反応物 2

HCID 260Hydrogen Bromide

HCID 57535357Methyl (S)-2-benzyloxycarbonylamino-4,4-difluoro-5-phenylpentanoate

生成物 1

HCID 66939992(S)-methyl 2-amino-4,4-difluoro-5-phenylpentanoate hydrobromide

実験手順

A mixture of (S)-methyl 2-(benzyloxycarbonylamino)-4,4-difluoro-5-phenylpentanoate (188 mg, 0.5 mmol) and hydrogen bromide (2 mL) was stirred at RT for two hr, after which the solvent was removed to give the title (S)-methyl 2-amino-4,4-difluoro-5-phenylpentanoate hydrobromide.

後処理

customafter which the solvent was removed

出典と根拠

ORDレコード: ord-c951b990760a4f349cdf94b6235ce274
出典データセット: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08367732B2

反応ノート

読み込み中…

参加物