4-(4-Bromo-2,6-difluoro-phenoxy)-tetrahydro-pyran → Rac-[1-(3,4-dichloro-phenyl)-2-[3,5-difluoro-4-(tetrahydro-pyran-4-yloxy)-phenyl]-2-oxo-ethyl]-carbamic acid tert-butyl ester

HRID 384916

反応式

HRID 384916 の反応式
[C:1]([O:5][C:6](=[O:23])[NH:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=1)[C:9](=[O:14])N(OC)C)([CH3:4])([CH3:3])[CH3:2].Br[C:25]1[CH:37]=[C:36]([F:38])[C:28]([O:29][CH:30]2[CH2:35][CH2:34][O:33][CH2:32][CH2:31]2)=[C:27]([F:39])[CH:26]=1>>[C:1]([O:5][C:6](=[O:23])[NH:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=1)[C:9]([C:25]1[CH:37]=[C:36]([F:38])[C:28]([O:29][CH:30]2[CH2:35][CH2:34][O:33][CH2:32][CH2:31]2)=[C:27]([F:39])[CH:26]=1)=[O:14])([CH3:2])([CH3:3])[CH3:4]

参加物

3

反応物 2

HCID 684092764-(4-Bromo-2,6-difluoro-phenoxy)-tetrahydro-pyran2 回HCID 87442373Rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester2 回

生成物 1

HCID 68410060Rac-[1-(3,4-dichloro-phenyl)-2-[3,5-difluoro-4-(tetrahydro-pyran-4-yloxy)-phenyl]-2-oxo-ethyl]-carbamic acid tert-butyl ester

実験手順

The title compound was prepared from rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester (Intermediate 9) and 4-(4-bromo-2,6-difluoro-phenoxy)-tetrahydro-pyran (Intermediate 18) in analogy to Example 1a): MS (ISP): 516.1 and 518.1 (M+H)+, 416.2 and 418.0 ((M-Boc)+H)+ (100%).

出典と根拠

ORDレコード
ord-abe192268957436c848b09cf772c0fa4
出典データセット
uspto-grants-2013_02
特許番号
US08367838B2

関連ノート

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