1,3-Difluoro-2-propanol → Rac-[1-(4-chloro-phenyl)-2-[4-(2-fluoro-1-fluoromethyl-ethoxy)-phenyl]-2-oxo-ethyl]-carbamic acid tert-butyl ester

HRID 384953

反応式

HRID 384953 の反応式
[C:1]([O:5][C:6](=[O:25])[NH:7][CH:8]([C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=1)[C:9]([C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=1)=[O:10])([CH3:4])([CH3:3])[CH3:2].[F:26][CH2:27][CH:28](O)[CH2:29][F:30]>>[C:1]([O:5][C:6](=[O:25])[NH:7][CH:8]([C:18]1[CH:19]=[CH:20][C:21]([Cl:24])=[CH:22][CH:23]=1)[C:9]([C:11]1[CH:16]=[CH:15][C:14]([O:17][CH:28]([CH2:29][F:30])[CH2:27][F:26])=[CH:13][CH:12]=1)=[O:10])([CH3:4])([CH3:2])[CH3:3]

参加物

3

反応物 2

HCID 679851,3-Difluoro-2-propanolHCID 68409176Rac-[1-(4-chloro-phenyl)-2-(4-hydroxy-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester

生成物 1

HCID 68410284Rac-[1-(4-chloro-phenyl)-2-[4-(2-fluoro-1-fluoromethyl-ethoxy)-phenyl]-2-oxo-ethyl]-carbamic acid tert-butyl ester

実験手順

The title compound was prepared from rac-[1-(4-chloro-phenyl)-2-(4-hydroxy-phenyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester and 1,3-difluoro-2-propanol in analogy to Example 9c): MS (ISN): 438.1 (M−H)−.

出典と根拠

ORDレコード
ord-3b7a58a02e804656aa7022a1d21093a3
出典データセット
uspto-grants-2013_02
特許番号
US08367838B2

関連ノート

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