Rac-[(4-chloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester → Rac-[1-(4-chloro-phenyl)-2-[2-fluoro-4-(2,2,3,3,3-pentafluoro-propoxy)-phenyl]-2-oxo-ethyl]-carbamic acid tert-butyl ester

HRID 384964

反応式

HRID 384964 の反応式
[C:1]([O:5][C:6](=[O:22])[NH:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=1)[C:9](=[O:14])N(OC)C)([CH3:4])([CH3:3])[CH3:2].Br[C:24]1[CH:29]=[CH:28][C:27]([O:30][CH2:31][C:32]([F:38])([F:37])[C:33]([F:36])([F:35])[F:34])=[CH:26][C:25]=1[F:39]>>[C:1]([O:5][C:6](=[O:22])[NH:7][CH:8]([C:15]1[CH:16]=[CH:17][C:18]([Cl:21])=[CH:19][CH:20]=1)[C:9]([C:24]1[CH:29]=[CH:28][C:27]([O:30][CH2:31][C:32]([F:37])([F:38])[C:33]([F:36])([F:35])[F:34])=[CH:26][C:25]=1[F:39])=[O:14])([CH3:2])([CH3:3])[CH3:4]

参加物

3

反応物 2

HCID 71663866Rac-[(4-chloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester2 回HCID 874432981-Bromo-2-fluoro-4-(2,2,3,3,3-pentafluoro-propoxy)-benzene2 回

生成物 1

HCID 87443451Rac-[1-(4-chloro-phenyl)-2-[2-fluoro-4-(2,2,3,3,3-pentafluoro-propoxy)-phenyl]-2-oxo-ethyl]-carbamic acid tert-butyl ester

実験手順

The title compound was prepared from rac-[(4-chloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester (Intermediate 8) and 1-bromo-2-fluoro-4-(2,2,3,3,3-pentafluoro-propoxy)-benzene (Intermediate 34) in analogy to Example 1a): MS (ISN): 510.3 (M−H)−.

出典と根拠

ORDレコード
ord-01e7387d733e4c04b6fbc4cae614dfb6
出典データセット
uspto-grants-2013_02
特許番号
US08367838B2

関連ノート

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