Toluene → 3-t-Butyl-5-cyano-4-methoxybenzoyl chloride
反応式
[C:1]([C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([C:16]#[N:17])[C:13]=1[O:14][CH3:15])[C:8](O)=[O:9])([CH3:4])([CH3:3])[CH3:2].C1(C)C=CC=CC=1.S(Cl)([Cl:27])=O>CN(C)C=O>[C:1]([C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([C:16]#[N:17])[C:13]=1[O:14][CH3:15])[C:8]([Cl:27])=[O:9])([CH3:4])([CH3:3])[CH3:2]参加物
5
反応条件
- 温度
- 60 °C
実験手順
To 3-t-butyl-5-cyano-4-methoxybenzoic acid (586 mg), toluene (10 mL), N,N-dimethylformamide (2 droplets) and thionyl chloride (0.27 mL) was added, and the mixture was stirred at 60° C. for 16 hours. The solvent was distilled off under reduced pressure and then azeotroped with toluene to obtain the title compound (630 mg) as a brown oily substance.
後処理
- distillationThe solvent was distilled off under reduced pressure
- customazeotroped with toluene
出典と根拠
- ORDレコード
- ord-ab39d87e500949cc8acb8858fd035b3d
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08367843B2
反応ノート
読み込み中…