Toluene → 3-Cyano-5-isopropyl-4-methoxybenzoyl chloride

HRID 385042ノート

反応式

HRID 385042 の反応式
[C:1]([C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([CH:14]([CH3:16])[CH3:15])[C:11]=1[O:12][CH3:13])[C:6](O)=[O:7])#[N:2].C1(C)C=CC=CC=1.S(Cl)([Cl:26])=O>CN(C)C=O>[C:1]([C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([CH:14]([CH3:16])[CH3:15])[C:11]=1[O:12][CH3:13])[C:6]([Cl:26])=[O:7])#[N:2]

参加物

5

反応物 3

HCID 1140TolueneHCID 24386Thionyl ChlorideHCID 681085253-Cyano-5-isopropyl-4-methoxybenzoic acid

生成物 1

HCID 866681543-Cyano-5-isopropyl-4-methoxybenzoyl chloride

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
60 °C

実験手順

To 3-cyano-5-isopropyl-4-methoxybenzoic acid (658 mg), toluene (7 mL), N,N-dimethylformamide (2 droplets) and thionyl chloride (0.33 mL) were added, and the mixture was stirred at 60° C. for 16 hours. The solvent was distilled off under reduced pressure and then azeotroped with toluene to obtain the title compound (710 mg) as a brown oily substance.

後処理

  1. distillationThe solvent was distilled off under reduced pressure
  2. customazeotroped with toluene

出典と根拠

ORDレコード
ord-19aa3623fe144d12a97a1e74075d5e69
出典データセット
uspto-grants-2013_02
特許番号
US08367843B2

反応ノート

読み込み中…