Toluene → HCID 86668171、化合物
反応式
[C:1]([C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([S:16]([CH3:19])(=[O:18])=[O:17])[C:13]=1[O:14][CH3:15])[C:8](O)=[O:9])([CH3:4])([CH3:3])[CH3:2].C1(C)C=CC=CC=1.S(Cl)([Cl:29])=O>CN(C)C=O>[C:1]([C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([S:16]([CH3:19])(=[O:18])=[O:17])[C:13]=1[O:14][CH3:15])[C:8]([Cl:29])=[O:9])([CH3:4])([CH3:3])[CH3:2]参加物
5
反応条件
- 温度
- 60 °C
実験手順
To 3-t-butyl-4-methoxy-5-methylsulfonyl benzoic acid (200 mg), toluene (4 mL), N,N-dimethylformamide (1 droplet) and thionyl chloride (80 μL) were added to the solution, and then the mixture was stirred at 60° C. for 16 hours. The solvent was distilled off under reduced pressure and the obtained residue was azeotroped with toluene and used for the synthesis of (f).