Toluene → 3-Formyl-4-methoxy-5-trifluoromethylbenzoyl chloride

HRID 385124ノート

反応式

HRID 385124 の反応式
[CH:1]([C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([C:14]([F:17])([F:16])[F:15])[C:11]=1[O:12][CH3:13])[C:6](O)=[O:7])=[O:2].C1(C)C=CC=CC=1.S(Cl)([Cl:27])=O>CN(C)C=O>[CH:1]([C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([C:14]([F:17])([F:16])[F:15])[C:11]=1[O:12][CH3:13])[C:6]([Cl:27])=[O:7])=[O:2]

参加物

5

反応物 3

HCID 1140TolueneHCID 24386Thionyl ChlorideHCID 866681493-Formyl-4-methoxy-5-trifluoromethylbenzoic acid

生成物 1

HCID 866681783-Formyl-4-methoxy-5-trifluoromethylbenzoyl chloride

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
60 °C

実験手順

To 3-formyl-4-methoxy-5-trifluoromethylbenzoic acid (2.05 g), toluene (20 mL), N,N-dimethylformamide (2 droplets) and thionyl chloride (0.70 mL) were added, and then the mixture was stirred at 60° C. for 6.5 hours. The solvent was distilled off under reduced pressure and then azeotroped with toluene to obtain the title compound (2.42 g) as a brown oily substance.

後処理

  1. distillationThe solvent was distilled off under reduced pressure
  2. customazeotroped with toluene

出典と根拠

ORDレコード
ord-361d9225f77b4c2fa808806f4aaf98f0
出典データセット
uspto-grants-2013_02
特許番号
US08367843B2

反応ノート

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