Lithium hydroxide, monohydrate → 3-Cyano-4-methoxybenzoic acid

HRID 385133

反応式

HRID 385133 の反応式
[C:1]([C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:12]=1[O:13][CH3:14])[C:6]([O:8]C)=[O:7])#[N:2].O.[OH-].[Li+]>O1CCCC1.O>[C:1]([C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:12]=1[O:13][CH3:14])[C:6]([OH:8])=[O:7])#[N:2]

参加物

5

反応物 2

HCID 168937Lithium hydroxide, monohydrateHCID 2801011Methyl 3-cyano-4-methoxybenzoate

生成物 1

HCID 219909723-Cyano-4-methoxybenzoic acid収率 92.6%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

Methyl 3-cyano-4-methoxybenzoate (879 mg) was dissolved in tetrahydrofuran (8 mL) and water (4 mL), and lithium hydroxide monohydrate (772 mg) was added to the solution, and then the mixture was stirred at mom temperature for 1 hour. The organic solvent was distilled off under reduced pressure and acidified with 2N hydrochloric acid, and then the precipitated crystal was collected by filtration to obtain the title compound (754 mg) as a colorless crystal.

後処理

  1. distillationThe organic solvent was distilled off under reduced pressure
  2. filtrationthe precipitated crystal was collected by filtration

出典と根拠

ORDレコード
ord-afce05d383564db4869144b7ab6bb707
出典データセット
uspto-grants-2013_02
特許番号
US08367843B2

関連ノート

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