Lithium hydroxide, monohydrate → 3-Cyano-4-methoxybenzoic acid
反応式
[C:1]([C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:12]=1[O:13][CH3:14])[C:6]([O:8]C)=[O:7])#[N:2].O.[OH-].[Li+]>O1CCCC1.O>[C:1]([C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:12]=1[O:13][CH3:14])[C:6]([OH:8])=[O:7])#[N:2]参加物
5
実験手順
Methyl 3-cyano-4-methoxybenzoate (879 mg) was dissolved in tetrahydrofuran (8 mL) and water (4 mL), and lithium hydroxide monohydrate (772 mg) was added to the solution, and then the mixture was stirred at mom temperature for 1 hour. The organic solvent was distilled off under reduced pressure and acidified with 2N hydrochloric acid, and then the precipitated crystal was collected by filtration to obtain the title compound (754 mg) as a colorless crystal.
後処理
- distillationThe organic solvent was distilled off under reduced pressure
- filtrationthe precipitated crystal was collected by filtration
出典と根拠
- ORDレコード
- ord-afce05d383564db4869144b7ab6bb707
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08367843B2
反応ノート
読み込み中…