Toluene → 3-Cyano-4-methoxy-5-trifluoromethoxybenzoyl chloride

HRID 385145ノート

反応式

HRID 385145 の反応式
[C:1]([C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([O:14][C:15]([F:18])([F:17])[F:16])[C:11]=1[O:12][CH3:13])[C:6](O)=[O:7])#[N:2].C1(C)C=CC=CC=1.S(Cl)([Cl:28])=O>CN(C)C=O>[C:1]([C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([O:14][C:15]([F:18])([F:17])[F:16])[C:11]=1[O:12][CH3:13])[C:6]([Cl:28])=[O:7])#[N:2]

参加物

5

反応物 3

HCID 1140TolueneHCID 24386Thionyl ChlorideHCID 681091153-Cyano-4-methoxy-5-trifluoromethoxybenzoic acid

生成物 1

HCID 866681833-Cyano-4-methoxy-5-trifluoromethoxybenzoyl chloride

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
60 °C

実験手順

To 3-cyano-4-methoxy-5-trifluoromethoxybenzoic acid (500 mg), toluene (10 mL), N,N-dimethylformamide (3 droplets) and thionyl chloride (0.28 mL) were added, and then the mixture was stirred at 60° C. for 6 hours. The solvent was distilled off under reduced pressure and the obtained residue was azeotroped with toluene and used for the synthesis of (i).

後処理

  1. distillationThe solvent was distilled off under reduced pressure
  2. customthe obtained residue was azeotroped with toluene
  3. customused for the synthesis of (i)

出典と根拠

ORDレコード
ord-2da99fd23d9a4913a70de0d32358d53b
出典データセット
uspto-grants-2013_02
特許番号
US08367843B2

反応ノート

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