Acetic Anhydride → Acetic acid-2-trifluoromethoxyphenyl ester

HRID 385148ノート

反応式

HRID 385148 の反応式
[F:1][C:2]([F:12])([F:11])[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[OH:10].C(N(CC)CC)C.[C:20](OC(=O)C)(=[O:22])[CH3:21].C(=O)([O-])[O-].[K+].[K+]>C(Cl)(Cl)Cl>[F:1][C:2]([F:11])([F:12])[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[O:10][C:20](=[O:22])[CH3:21]

参加物

6

反応物 4

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 11430Potassium CarbonateHCID 27772992-(Trifluoromethoxy)phenol

生成物 1

HCID 20717723Acetic acid-2-trifluoromethoxyphenyl ester

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

2-trifluoromethoxyphenol (10.00 g) was dissolved in chloroform (30 mL), and triethylamine (6.11 mL) and acetic anhydride (6.37 mL) was added to the solution, and then the mixture was stirred at room temperature for 2 hours. To the reaction solution, 10% potassium carbonate was added, and then the mixture was extracted with chloroform. The organic layer was washed with an aqueous 5% citric acid solution and saturated brine, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain the title compound (11.39 g) as a colorless oily substance.

後処理

  1. extractionthe mixture was extracted with chloroform
  2. washThe organic layer was washed with an aqueous 5% citric acid solution and saturated brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. distillationThe solvent was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-4e02bb7a1d944516a07b4431bdf03a3b
出典データセット
uspto-grants-2013_02
特許番号
US08367843B2

反応ノート

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