3-Chloro-4-fluoroaniline → N-(3-Chloro-4-fluorophenyl)-6,7,8,9-tetrahydro-5H-pyrimido[5',4':4,5]thieno[2,3-d]azepin-4-amine

HRID 38565

反応式

HRID 38565 の反応式
Cl[C:2]1[C:7]2[C:8]3[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10][C:9]=3[S:22][C:6]=2[N:5]=[CH:4][N:3]=1.[Cl:23][C:24]1[CH:25]=[C:26]([CH:28]=[CH:29][C:30]=1[F:31])[NH2:27]>>[Cl:23][C:24]1[CH:25]=[C:26]([NH:27][C:2]2[C:7]3[C:8]4[CH2:14][CH2:13][NH:12][CH2:11][CH2:10][C:9]=4[S:22][C:6]=3[N:5]=[CH:4][N:3]=2)[CH:28]=[CH:29][C:30]=1[F:31]

参加物

3

反応物 2

HCID 97083-Chloro-4-fluoroanilineHCID 58116942tert-Butyl 4-chloro-5,6,8,9-tetrahydro-7H-pyrimido[5',4':4,5]thieno[2,3-d]azepine-7-carboxylate

生成物 1

HCID 66850022N-(3-Chloro-4-fluorophenyl)-6,7,8,9-tetrahydro-5H-pyrimido[5',4':4,5]thieno[2,3-d]azepin-4-amine

実験手順

The title compound was prepared in analogy to Example 12A from tert-butyl 4-chloro-5,6,8,9-tetrahydro-7H-pyrimido[5′,4′:4,5]thieno[2,3-d]azepine-7-carboxylate from Example 84A (680 mg, 2.00 mmol) and 3-chloro-4-fluoroaniline (306 mg, 2.10 mmol) to yield 419 mg (60%).

後処理

  1. customto yield 419 mg (60%)

出典と根拠

ORDレコード
ord-bebfec6126034f30b4fe6f76eaf11fd8
出典データセット
uspto-grants-2013_09
特許番号
US08524722B2

関連ノート

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