5-[4-(Methylsulfonyl)phenyl]-2-nitrothiophene-3-carboxamide → 2-Amino-5-[4-(methylsulfonyl)phenyl]thiophene-3-carboxamide

HRID 385715ノート

反応式

HRID 385715 の反応式
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[S:15][C:14]([N+:16]([O-])=O)=[C:13]([C:19]([NH2:21])=[O:20])[CH:12]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3]>CO.[Pt]>[NH2:16][C:14]1[S:15][C:11]([C:8]2[CH:7]=[CH:6][C:5]([S:2]([CH3:1])(=[O:4])=[O:3])=[CH:10][CH:9]=2)=[CH:12][C:13]=1[C:19]([NH2:21])=[O:20]

参加物

4

反応物 1

HCID 595257655-[4-(Methylsulfonyl)phenyl]-2-nitrothiophene-3-carboxamide

生成物 1

HCID 582564812-Amino-5-[4-(methylsulfonyl)phenyl]thiophene-3-carboxamide

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 887Methanol溶媒

実験手順

Nitro reduction, Method A: 5-[4-(Methylsulfonyl)phenyl]-2-nitrothiophene-3-carboxamide (0.96 g, 2.94 mmol) and Pt/C, doped with V (0.191 g, 0.029 mmol) were stirred in MeOH (60 mL) at room temperature under a balloon of H2 for 90 minutes. The catalyst was removed by filtering through Celite, which was subsequently washed with DMF. The solvent was removed in vacuo and the residue triturated in EtOH to give the title compound as a dark brown solid.

後処理

  1. customThe catalyst was removed
  2. filtrationby filtering through Celite, which
  3. washwas subsequently washed with DMF
  4. customThe solvent was removed in vacuo
  5. customthe residue triturated in EtOH

出典と根拠

ORDレコード
ord-6d60e84ed0044eb395e6fdf29b43a93b
出典データセット
uspto-grants-2013_02
特許番号
US08367706B2

反応ノート

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