Water → 5-[4-(1-Hydroxyethyl)phenyl]-2-nitrothiophene-3-carboxamide

HRID 385726ノート

反応式

HRID 385726 の反応式
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[S:14][C:13]([N+:15]([O-:17])=[O:16])=[C:12]([C:18]([NH2:20])=[O:19])[CH:11]=2)=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[BH4-].[Na+].O>CO>[OH:3][CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[S:14][C:13]([N+:15]([O-:17])=[O:16])=[C:12]([C:18]([NH2:20])=[O:19])[CH:11]=2)=[CH:6][CH:5]=1)[CH3:2]

参加物

5

反応物 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 595260295-(4-Acetylphenyl)-2-nitrothiophene-3-carboxamide

生成物 1

HCID 595257315-[4-(1-Hydroxyethyl)phenyl]-2-nitrothiophene-3-carboxamide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

5-(4-Acetylphenyl)-2-nitrothiophene-3-carboxamide (0.21 g, 0.723 mmol) was taken up in MeOH (4 mL), followed by the addition of sodium borohydride (0.027 g, 0.723 mmol). The reaction mixture stirred at room temperature for 3 hours. Water was added and the products extracted into EtOAc (2×). The combined organic extracts were washed with brine, dried over MgSO4, filtered, and concentrated in vacuo to give the title compound as a yellow solid.

後処理

  1. extractionthe products extracted into EtOAc (2×)
  2. washThe combined organic extracts were washed with brine
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-f70ad1fd60414e27a90a0ab4d63d3b9d
出典データセット
uspto-grants-2013_02
特許番号
US08367706B2

反応ノート

読み込み中…