Sodium borohydride → 1-(6-Bromo-2-pyridinyl)ethanol

HRID 385756ノート

反応式

HRID 385756 の反応式
[Br:1][C:2]1[N:7]=[C:6]([C:8](=[O:10])[CH3:9])[CH:5]=[CH:4][CH:3]=1.[BH4-].[Na+]>CO.ClCCl.O>[Br:1][C:2]1[N:7]=[C:6]([CH:8]([OH:10])[CH3:9])[CH:5]=[CH:4][CH:3]=1

参加物

6

反応物 2

HCID 4311764Sodium borohydrideHCID 112985782-Acetyl-6-bromopyridine

生成物 1

HCID 110634791-(6-Bromo-2-pyridinyl)ethanol

試薬・触媒・溶媒 3

HCID 887Methanol溶媒HCID 962Water溶媒HCID 6344Dichloromethane溶媒

実験手順

A solution of 1-(6-bromopyridin-2-yl)ethanone (2.9636 g, 14.82 mmol) in methanol (40 mL) at 0° C. was charged with sodium borohydride (1.682 g, 44.4 mmol) and then allowed to warm to room temperature. After 2.5 hours, the reaction mixture was diluted with dichloromethane (60 mL) and water (60 mL) and the layers were separated. The organic layer was dried over sodium sulfate, filtered, and concentrated to yield the title compound.

後処理

  1. customthe layers were separated
  2. dry with materialThe organic layer was dried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-7d668943413840dabfbdd461a0cf7016
出典データセット
uspto-grants-2013_02
特許番号
US08367706B2

反応ノート

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