Morpholine → 1-(6-Bromopyridin-2-yl)-2-morpholin-4-ylethanone

HRID 385796ノート

反応式

HRID 385796 の反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([Br:11])[N:6]=1)=[O:4].[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>O1CCCC1.CN(C)C=O.C(OCC)(=O)C>[Br:11][C:7]1[N:6]=[C:5]([C:3](=[O:4])[CH2:2][N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[CH:10]=[CH:9][CH:8]=1

参加物

6

反応物 2

HCID 8083MorpholineHCID 534075852-Bromo-1-(6-bromopyridin-2-yl)ethan-1-one

生成物 1

HCID 595263201-(6-Bromopyridin-2-yl)-2-morpholin-4-ylethanone

試薬・触媒・溶媒 3

HCID 6228Dimethylformamide溶媒HCID 8028Tetrahydrofuran溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 2-bromo-1-(6-bromopyridin-2-yl)ethanone (250 mg, 0.90 mmol) in tetrahydrofuran (1 mL) and dimethylformamide (1 mL) was added morpholine (0.18 mL, 2.0 mmol). After 45 minutes, the reaction mixture was diluted with ethyl acetate (30 mL) and washed with saturated aqueous sodium bicarbonate (15 mL) and brine (15 mL). The organic layer was dried over sodium sulfate, filtered, and concentrated to afford the title compound.

後処理

  1. washwashed with saturated aqueous sodium bicarbonate (15 mL) and brine (15 mL)
  2. dry with materialThe organic layer was dried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-4c1d8ce65b514d8d8625714bfe11e6e3
出典データセット
uspto-grants-2013_02
特許番号
US08367706B2

反応ノート

読み込み中…