Formic Acid → 1-(6-Bromopyridin-2-yl)-2-morpholin-4-ylethanol

HRID 385797ノート

反応式

HRID 385797 の反応式
[Br:1][C:2]1[N:7]=[C:6]([C:8](=[O:16])[CH2:9][N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[CH:5]=[CH:4][CH:3]=1.[BH4-].[Na+].C(O)=O>CO.C(OCC)(=O)C.C(=O)(O)[O-].[Na+].O>[Br:1][C:2]1[N:7]=[C:6]([CH:8]([OH:16])[CH2:9][N:10]2[CH2:11][CH2:12][O:13][CH2:14][CH2:15]2)[CH:5]=[CH:4][CH:3]=1

参加物

8

反応物 3

HCID 284Formic AcidHCID 4311764Sodium borohydrideHCID 595263201-(6-Bromopyridin-2-yl)-2-morpholin-4-ylethanone

生成物 1

HCID 595260601-(6-Bromopyridin-2-yl)-2-morpholin-4-ylethanol

試薬・触媒・溶媒 4

HCID 887Methanol溶媒HCID 962Water溶媒HCID 8857Ethyl Acetate溶媒HCID 516892Sodium Bicarbonate溶媒

実験手順

To a solution of 1-(6-bromopyridin-2-yl)-2-morpholin-4-ylethanone (234 mg, 0.82 mmol) in methanol at 0° C. was added sodium borohydride (31.0 mg, 0.82 mmol). After 30 minutes, formic acid (0.1 mL) was added and then the reaction mixture was diluted with ethyl acetate (40 mL), saturated aqueous sodium bicarbonate (10 mL), and water (10 mL). The layers were separated and the organic layer was washed with brine (10 mL), dried over sodium sulfate, filtered, and concentrated to give the title compound.

後処理

  1. customThe layers were separated
  2. washthe organic layer was washed with brine (10 mL)
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-c55cd15ae1fc47f487154705eca98c17
出典データセット
uspto-grants-2013_02
特許番号
US08367706B2

反応ノート

読み込み中…