Tetrabutylammonium Fluoride → (4R)-1-[(6-bromopyridin-2-yl)methyl]-4-hydroxypyrrolidin-2-one
反応式
[Br:1][C:2]1[N:7]=[C:6]([CH2:8][N:9]2[CH2:13][C@H:12]([O:14][Si](C(C)(C)C)(C)C)[CH2:11][C:10]2=[O:22])[CH:5]=[CH:4][CH:3]=1.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1>[Br:1][C:2]1[N:7]=[C:6]([CH2:8][N:9]2[CH2:13][C@H:12]([OH:14])[CH2:11][C:10]2=[O:22])[CH:5]=[CH:4][CH:3]=1参加物
4
実験手順
(4R)-1-[(6-Bromopyridin-2-yl)methyl]-4-{[tert-butyl(dimethyl)silyl]oxy}pyrrolidin-2-one was dissolved in tetrahydrofuran (33.4 mL), and tetrabutylammonium fluoride (5.84 mL, 5.84 mmol) was added dropwise and the solution stirred at ambient temperature for five minutes. The reaction mixture was concentrated and purified by silica gel chromatography to yield the title compound.
後処理
- concentrationThe reaction mixture was concentrated
- custompurified by silica gel chromatography
出典と根拠
- ORDレコード
- ord-54d2202d4cfe4e1686764915b555f412
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08367706B2
反応ノート
読み込み中…