Water → 2-(1-Methyl-1H-pyrazol-4-yl)ethan-1-ol

HRID 385887

反応式

HRID 385887 の反応式
[NH:1]1[CH:5]=[C:4]([CH2:6][CH2:7][OH:8])[CH:3]=[N:2]1.[OH-].[K+].[CH3:11]I.O>C(O)C>[CH3:11][N:1]1[CH:5]=[C:4]([CH2:6][CH2:7][OH:8])[CH:3]=[N:2]1

参加物

6

反応物 4

HCID 962WaterHCID 6328Methyl iodideHCID 14797Potassium HydroxideHCID 42936042-(1H-Pyrazol-4-yl)ethanol

生成物 1

HCID 170280762-(1-Methyl-1H-pyrazol-4-yl)ethan-1-ol

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution cooled (0° C.) of 2-(1H-pyrazol-4-yl)ethanol (93 g, 0.83 mol) and potassium hydroxide (48.8 g, 0.87 mol) in absolute ethanol (9.25 L) was added methyl iodide (178 g, 1.25 mol) dropwise. The mixture was allowed to react for 30 min, at which time it was poured into water (400 mL) and extracted with diethyl ether (4×100 mL). The combined organic layers were dried (Na2SO4), filtered, concentrated in vacuo, and purified by vacuum distillation to afford the title compound.

後処理

  1. customto react for 30 min, at which time it
  2. extractionextracted with diethyl ether (4×100 mL)
  3. dry with materialThe combined organic layers were dried (Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo
  6. distillationpurified by vacuum distillation

出典と根拠

ORDレコード
ord-925e031597ef44eda47f838e3ea4011f
出典データセット
uspto-grants-2013_02
特許番号
US08367706B2

関連ノート

読み込み中…