Thionyl Chloride → 4-(2-chloroethyl)-1-methyl-1H-pyrazole

HRID 385888

反応式

HRID 385888 の反応式
[CH3:1][N:2]1[CH:6]=[C:5]([CH2:7][CH2:8]O)[CH:4]=[N:3]1.S(Cl)([Cl:12])=O>>[Cl:12][CH2:8][CH2:7][C:5]1[CH:4]=[N:3][N:2]([CH3:1])[CH:6]=1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 170280762-(1-Methyl-1H-pyrazol-4-yl)ethanol

生成物 1

HCID 595256864-(2-chloroethyl)-1-methyl-1H-pyrazole

実験手順

To excess thionyl chloride (250 mL) at 0° C. was added 2-(1-methyl-1H-pyrazol-4-yl)ethanol (82 g, 0.651 mol). The reaction mixture was heated to reflux for 15 minutes. The excess thionyl chloride was removed in vacuo and the crude product was purified by recrystallization from EtOH to afford the title compound.

後処理

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 15 minutes
  3. customThe excess thionyl chloride was removed in vacuo
  4. customthe crude product was purified by recrystallization from EtOH

出典と根拠

ORDレコード
ord-8cf3da863bb44cb5b5e5721caf418352
出典データセット
uspto-grants-2013_02
特許番号
US08367706B2

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