Sodium borohydride → (6-Chloro-2-methylpyridin-3-yl)methanol

HRID 385945ノート

反応式

HRID 385945 の反応式
[BH4-].[Na+].[Cl:3][C:4]1[CH:11]=[CH:10][C:7]([CH:8]=[O:9])=[C:6]([CH3:12])[N:5]=1>CO>[Cl:3][C:4]1[N:5]=[C:6]([CH3:12])[C:7]([CH2:8][OH:9])=[CH:10][CH:11]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 447548676-Chloro-2-methylpyridine-3-carbaldehyde

生成物 1

HCID 59525984(6-Chloro-2-methylpyridin-3-yl)methanol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Sodium borohydride (0.73 g, 19.28 mmol) was added to a solution of 6-chloro-2-methylnicotinaldehyde (1.5 g, 9.64 mmol) in methanol (38.6 mL) at room temperature. The mixture was stirred for 2 hours, then quenched with water and saturated aqueous sodium bicarbonate, and extracted three times with ethyl acetate. The organic layers were combined, dried over magnesium sulfate, filtered, and concentrated under reduced pressure to afford the title compound.

後処理

  1. customquenched with water and saturated aqueous sodium bicarbonate
  2. extractionextracted three times with ethyl acetate
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-793b09812c5f4bde9dc40ab0690a36f3
出典データセット
uspto-grants-2013_02
特許番号
US08367706B2

反応ノート

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