m-Chloroperbenzoic acid → Methyl 2-methylnicotinate 1-oxide

HRID 385949

反応式

HRID 385949 の反応式
[CH3:1][C:2]1[C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.C1C=C(Cl)C=C(C(OO)=[O:20])C=1>C(Cl)Cl>[CH3:1][C:2]1[C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=[CH:4][N+:3]=1[O-:20]

参加物

4

反応物 2

HCID 70297m-Chloroperbenzoic acidHCID 7015327Methyl 2-methylnicotinate

生成物 1

HCID 20163965Methyl 2-methylnicotinate 1-oxide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Methyl 2-methylpyridine-3-carboxylate (10 g, 66.2 mmol) was taken up in DCM (140 mL) and mCPBA (16.31 g, 72.8 mmol) was added. The resulting mixture was allowed to react at room temperature overnight and then purified directly by silica gel chromatography (0-20% MeOH-EtOAc) to afford the title compound as a beige solid.

後処理

  1. customto react at room temperature overnight
  2. custompurified directly by silica gel chromatography (0-20% MeOH-EtOAc)

出典と根拠

ORDレコード
ord-256fc36ad7554edebbbcc4d54d39a313
出典データセット
uspto-grants-2013_02
特許番号
US08367706B2

関連ノート

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