Tetrahydrofuran → 1-(6-Chloro-2-methylpyridin-3-yl)-2,2,2-trifluoroethanol

HRID 386005ノート

反応式

HRID 386005 の反応式
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([CH3:10])[N:3]=1.O1CCCC1.C[Si](C)(C)[C:18]([F:21])([F:20])[F:19].[F-].C([N+](CCCC)(CCCC)CCCC)CCC>O.[Cl-].[Na+].O>[Cl:1][C:2]1[N:3]=[C:4]([CH3:10])[C:5]([CH:6]([OH:7])[C:18]([F:21])([F:20])[F:19])=[CH:8][CH:9]=1

参加物

7

反応物 4

HCID 8028TetrahydrofuranHCID 552549(Trifluoromethyl)trimethylsilaneHCID 2724141Tetrabutylammonium FluorideHCID 447548676-Chloro-2-methylpyridine-3-carbaldehyde

生成物 1

HCID 595259381-(6-Chloro-2-methylpyridin-3-yl)-2,2,2-trifluoroethanol

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 57417360Sodium chloride; water溶媒

反応条件

温度
0 °C

実験手順

6-Chloro-2-methylnicotinaldehyde (250 mg, 1.6 mmol) was added to tetrahydrofuran (10.7 ml) and cooled to 0° C. Trimethyl(trifluoromethyl)silane (0.3 ml, 1.9 mmol) was added followed by tetrabutylammonium fluoride (1.9 ml, 1.0M in THF, 1.9 mmol). The reaction mixture was allowed to warm to room temperature over 1 hour. The reaction was then diluted with water and brine and extracted with ethyl acetate (3×). The organic layers were combined and dried over magnesium sulfate, filtered, and concentrated in vacuo to yield the title compound as a solid.

後処理

  1. temperatureto warm to room temperature over 1 hour
  2. extractionextracted with ethyl acetate (3×)
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-1933638380db4105be44aae2d82dcffd
出典データセット
uspto-grants-2013_02
特許番号
US08367706B2

反応ノート

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