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Potassium Hydroxide → Potassium 1-{[6-({3-(aminocarbonyl)-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-thienyl}amino)pyridin-2-yl]methyl}-1H-1,2,3-triazole-4-carboxylate

HRID 386042
ノート
印刷プレビュー

反応式

HRID 386042 の反応式
[NH2:1][C:2]([C:4]1[CH:8]=[C:7]([C:9]2[C:14]([F:15])=[CH:13][C:12]([C:16]([OH:19])([CH3:18])[CH3:17])=[CH:11][C:10]=2[F:20])[S:6][C:5]=1[NH:21][C:22]1[N:27]=[C:26]([CH2:28][N:29]2[CH:33]=[C:32]([C:34]([O:36]C)=[O:35])[N:31]=[N:30]2)[CH:25]=[CH:24][CH:23]=1)=[O:3].[OH-].[K+:39]>C1COCC1.CO>[NH2:1][C:2]([C:4]1[CH:8]=[C:7]([C:9]2[C:10]([F:20])=[CH:11][C:12]([C:16]([OH:19])([CH3:17])[CH3:18])=[CH:13][C:14]=2[F:15])[S:6][C:5]=1[NH:21][C:22]1[N:27]=[C:26]([CH2:28][N:29]2[CH:33]=[C:32]([C:34]([O-:36])=[O:35])[N:31]=[N:30]2)[CH:25]=[CH:24][CH:23]=1)=[O:3].[K+:39]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 2

HCID 14797Potassium Hydroxide2 回HCID 59525991Methyl 1-{[6-({3-(aminocarbonyl)-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-thienyl}amino)pyridin-2-yl]methyl}-1H-1,2,3-triazole-4-carboxylate

生成物 1

HCID 68671625Potassium 1-{[6-({3-(aminocarbonyl)-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-thienyl}amino)pyridin-2-yl]methyl}-1H-1,2,3-triazole-4-carboxylate

試薬・触媒・溶媒 2

HCID 887Methanol
溶媒
HCID 8028Tetrahydrofuran溶媒

実験手順

Methyl 1-{[6-({3-(aminocarbonyl)-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-thienyl}amino)pyridin-2-yl]methyl}-1H-1,2,3-triazole-4-carboxylate (425 mg, 0.80 mmol) was taken up in THF (5.0 mL) and MeOH (5.0 mL), and KOH (1.0 M, 1.05 mL, 1.05 mmol) was added. The reaction was stirred at room temperature overnight. Additional KOH (1.0 M, 160 μL, 0.16 mmol) was added, and the reaction was stirred for another 8 h at room temperature. The mixture was then concentrated, resuspended in MeOH, and concentrated again to give the title compound as a yellow solid that was carried on without purification.

後処理

  1. stirringthe reaction was stirred for another 8 h at room temperature
  2. concentrationThe mixture was then concentrated
  3. concentrationconcentrated again

出典と根拠

ORDレコード
ord-6e0a57545f464426ba6669a6b8d6668e
出典データセット
uspto-grants-2013_02
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08367706B2

反応ノート

読み込み中…

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