Sodium Bicarbonate → HCID 178448789、化合物

HRID 386127ノート

反応式

HRID 386127 の反応式
[C:1]([C:3]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[S:16][C:15]([NH:17][C:18]3[CH:23]=[CH:22][N:21]=[C:20]([O:24]CC[Si](C)(C)C)[N:19]=3)=[C:14]([C:31]([NH2:33])=[O:32])[CH:13]=2)=[CH:8][CH:7]=1)([CH3:5])[CH3:4])#[N:2].C([O-])(O)=O.[Na+]>C(Cl)Cl.C(O)(C(F)(F)F)=O>[C:1]([C:3]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[S:16][C:15]([NH:17][C:18]3[CH:23]=[CH:22][NH:21][C:20](=[O:24])[N:19]=3)=[C:14]([C:31]([NH2:33])=[O:32])[CH:13]=2)=[CH:8][CH:7]=1)([CH3:5])[CH3:4])#[N:2]

参加物

5

反応物 2

HCID 516892Sodium BicarbonateHCID 595256505-[4-(1-Cyano-1-methylethyl)phenyl]-2-({2-[2-(trimethylsilyl)ethoxy]pyrimidin-4-yl}amino)thiophene-3-carboxamide

生成物 1

HCID 178448789HCID 178448789、化合物

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 6422Trifluoroacetic acid溶媒

実験手順

5-[4-(1-Cyano-1-methylethyl)phenyl]-2-({2-[2-(trimethylsilyl)ethoxy]pyrimidin-4-yl}amino)thiophene-3-carboxamide (107 mg, 0.223 mmol) was stirred in a mixture of DCM (5 mL) and TFA (2 mL) at room temperature for 30 minutes. Saturated NaHCO3 was added and the resulting precipitate collected by filtration and washed with water and DCM to give the title compound as a yellow solid.

後処理

  1. filtrationthe resulting precipitate collected by filtration
  2. washwashed with water and DCM

出典と根拠

ORDレコード
ord-7a7389dbc9984a48a00cc8cce57457a0
出典データセット
uspto-grants-2013_02
特許番号
US08367706B2

反応ノート

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