p-Toluenesulfonic acid → 4-Propyl-cyclohexanecarboxylic acid 4-acryloyloxy-butyl ester

HRID 386334

反応式

HRID 386334 の反応式
[CH2:1]([CH:4]1[CH2:9][CH2:8][CH:7]([C:10]([OH:12])=[O:11])[CH2:6][CH2:5]1)[CH2:2][CH3:3].[C:13]([O:17][CH2:18][CH2:19][CH2:20][CH2:21]O)(=[O:16])[CH:14]=[CH2:15].C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[C:13]([O:17][CH2:18][CH2:19][CH2:20][CH2:21][O:11][C:10]([CH:7]1[CH2:8][CH2:9][CH:4]([CH2:1][CH2:2][CH3:3])[CH2:5][CH2:6]1)=[O:12])(=[O:16])[CH:14]=[CH2:15]

参加物

5

反応物 3

HCID 6101p-Toluenesulfonic acidHCID 755884-Hydroxybutyl acrylateHCID 1490324(1s,4r)-4-Propylcyclohexane-1-carboxylic acid

生成物 1

HCID 592890904-Propyl-cyclohexanecarboxylic acid 4-acryloyloxy-butyl ester

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

4-Propyl-cyclohexanecarboxylic acid (10.0 g, 58.0 mmol), 4-hydroxybutyl acrylate (8.0 g, 57.0 mmol) and a catalytic amount of para-toluene sulphonic acid are stirred under reflux in toluene (100 ml) in a flask equipped with Dean-Stark apparatus. The reaction is shown to be complete by GCMS after 1 hour. The solution is allowed to cool to room temperature, is washed with aqueous sodium carbonate and water, dried and evaporated to dryness. Purification is achieved by flash column chromatography using petrol as eluant. Evaporation of the appropriate fractions gives a colourless oil.

後処理

  1. customequipped with Dean-Stark apparatus
  2. washis washed with aqueous sodium carbonate and water
  3. customdried
  4. customevaporated to dryness
  5. customPurification
  6. customEvaporation of the appropriate fractions
  7. customgives a colourless oil

出典と根拠

ORDレコード
ord-a2e30c497dba4744a6945527d75788a1
出典データセット
uspto-grants-2013_02
特許番号
US08372307B2

関連ノート

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