2-Hydroxy-3''-nitro-biphenyl-3-carboxylic acid → 3-(3-Amino-2-hydroxyphenyl)benzoic acid
反応式
[OH:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][CH:5]=[CH:4][C:3]=1[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([OH:19])=[O:18])[CH:12]=1>CO.[Pd]>[NH2:8][C:7]1[C:2]([OH:1])=[C:3]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([OH:19])=[O:18])[CH:12]=2)[CH:4]=[CH:5][CH:6]=1参加物
4
実験手順
A solution of 2′-hydroxy-3′-nitrobiphenyl-3-carboxylic acid (800 g, 3.2 mol) in methanol (5 L) was hydrogenated over 5 Pd/C (160 g) at room temperature for 8 hours. The reaction mixture was filtered, concentrated and slurried in THF (2.5 L) to give 3′-amino-2′-hydroxybiphenyl-3-carboxylic acid (690 g, 50.5%) as a brown solid. PXRD analysis provided the diffractogram as shown in FIG. 32.
後処理
- filtrationThe reaction mixture was filtered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-63e5ce883fcb43b1b93c05ee2ab4d6cd
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08372822B2
反応ノート
読み込み中…