Sodium Azide → 5-Azidopentanoic acid ethyl ester

HRID 386421ノート

反応式

HRID 386421 の反応式
Br[CH2:2][CH2:3][CH2:4][CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7].[N-:11]=[N+:12]=[N-:13].[Na+]>CN(C)C=O.O>[N:11]([CH2:2][CH2:3][CH2:4][CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7])=[N+:12]=[N-:13]

参加物

5

反応物 2

HCID 33557Sodium AzideHCID 84580Ethyl 5-bromovalerate

生成物 1

HCID 123821765-Azidopentanoic acid ethyl ester収率 95%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

Ethyl 5-bromovalerate (2.1 g; 10 mmol; Aldrich) was added to a stirred suspension of sodium azide (1.3 g, 20 mmol; Fisher) in 5 ml dimethylformamide and 5 ml water, and the reaction mixture was heated 12 h at 80° Cs. The reaction was partitioned between diethyl ether (100 ml) and water (100 ml), and the resulting organic layer was washed with water (100 ml) and brine (100 ml), dried over sodium sulfate, and dried in vacuo. Yield: 1.6 g (9.3 mmol, 95% yield).

後処理

  1. temperaturethe reaction mixture was heated 12 h at 80° Cs
  2. customThe reaction was partitioned between diethyl ether (100 ml) and water (100 ml)
  3. washthe resulting organic layer was washed with water (100 ml) and brine (100 ml)
  4. dry with materialdried over sodium sulfate
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-ebf09f29840241ea95cb9dc7b6c8384b
出典データセット
uspto-grants-2013_02
特許番号
US08372839B2

反応ノート

読み込み中…