Methyl iodide → Methyl 3-(benzyloxy)-5-methoxybenzoate

HRID 38655ノート

反応式

HRID 38655 の反応式
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:16]=[C:17]([OH:19])[CH:18]=1)[C:12]([O:14][CH3:15])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:20](=O)([O-])[O-].[K+].[K+].IC>CC(C)=O>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:16]=[C:17]([O:19][CH3:20])[CH:18]=1)[C:12]([O:14][CH3:15])=[O:13])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 7472028Methyl 3-(benzyloxy)-5-hydroxybenzoate

生成物 1

HCID 12658782Methyl 3-(benzyloxy)-5-methoxybenzoate収率 85%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A suspension of 4.0 g (0.0165 mmol) methyl 3-(benzyloxy)-5-hydroxybenzoate (160), 6.84 g (0.0495 mmol) potassium carbonate, and 11.71 g (0.0825 mmol) iodomethane in the 200 mL of acetone was stirred at room temperature for 24 h. After the mixture was filtered and evaporated, the residue was washed with water. The methyl 3-(benzyloxy)-5-methoxybenzoate (161) was obtained as a white solid.

後処理

  1. filtrationAfter the mixture was filtered
  2. customevaporated
  3. washthe residue was washed with water

出典と根拠

ORDレコード
ord-34cdac811085477c8b89e990af9512d2
出典データセット
uspto-grants-2013_09
特許番号
US08524740B2

反応ノート

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