Sodium Hydroxide → 3-(Benzyloxy)-5-methoxybenzoic acid

HRID 38656ノート

反応式

HRID 38656 の反応式
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:16]=[C:17]([O:19][CH3:20])[CH:18]=1)[C:12]([O:14]C)=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C.O>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:16]=[C:17]([O:19][CH3:20])[CH:18]=1)[C:12]([OH:14])=[O:13])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 12658782Methyl 3-(benzyloxy)-5-methoxybenzoate

生成物 1

HCID 126587813-(Benzyloxy)-5-methoxybenzoic acid収率 90%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

4.45 g (0.0174 mmol) of methyl 3-(benzyloxy)-5-methoxybenzoate (161) was suspended in 120 mL of 95% ethanol and 5 mL water. An amount of 2.00 g (0.05 mmol) of sodium hydroxide was added. The mixture was heated at reflux for 1 h. After the mixture was evaporated, the residue was quenched with 150 mL of water. The solution was neutralized with dil aq HCl and then the precipitate was collected and washed with water and acetone to give 162.

後処理

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 1 h
  3. customAfter the mixture was evaporated
  4. customthe residue was quenched with 150 mL of water
  5. customthe precipitate was collected
  6. washwashed with water and acetone

出典と根拠

ORDレコード
ord-b7cce4cbf9a24832b82a74bb5d1139c9
出典データセット
uspto-grants-2013_09
特許番号
US08524740B2

反応ノート

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