Thionyl Chloride → 3-(Benzyloxy)-5-methoxybenzoyl chloride

HRID 38657

反応式

HRID 38657 の反応式
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:15]=[C:16]([O:18][CH3:19])[CH:17]=1)[C:12](O)=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:22])=O>C1(C)C=CC=CC=1.CN(C)C=O>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:15]=[C:16]([O:18][CH3:19])[CH:17]=1)[C:12]([Cl:22])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 24386Thionyl ChlorideHCID 126587813-(Benzyloxy)-5-methoxybenzoic acid

生成物 1

HCID 126587833-(Benzyloxy)-5-methoxybenzoyl chloride

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 1140Toluene溶媒

実験手順

3-(Benzyloxy)-5-methoxybenzoic acid (162) (2.57 g, 0.01 mmol) and thionyl chloride (4.80 g, 0.04 mmol) were suspended in 200 mL of dry toluene. The reaction mixture was stirred for 30 min and then dimethyl formamide (3 drops) was added. The mixture was stirred for 24 h and then evaporated to dryness. The residue was directly used for the next step without further purification.

後処理

  1. stirringThe mixture was stirred for 24 h
  2. customevaporated to dryness
  3. customThe residue was directly used for the next step without further purification

出典と根拠

ORDレコード
ord-3c9d93c5e3544b2ab3e9203f54d79d47
出典データセット
uspto-grants-2013_09
特許番号
US08524740B2

関連ノート

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