Acetone → 4-Chlorobenzalacetone

HRID 38663

反応式

HRID 38663 の反応式
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.[OH-].[Na+].O.[CH3:13][C:14]([CH3:16])=[O:15]>C(O)C>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[CH:13][C:14](=[O:15])[CH3:16])=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 180AcetoneHCID 962WaterHCID 77264-ChlorobenzaldehydeHCID 14798Sodium Hydroxide

生成物 1

HCID 981834-Chlorobenzalacetone収率 96.9%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
25 °C

実験手順

To the solution of 4-chlorobenzaldehyde (8.43 g, 60 mmol) in acetone(60 ml) and ethanol (6 ml) was added under stirring 10% NaOH aqueous solution(48 ml) and water(240 ml), the reaction solution was stirred at 25° C. for 8 hr. The precipitated solid was collected by filtration and washed with water, dried to give the title compound 10.5 g as a white solid, mp 56-57° C., yield: 96.9%.

後処理

  1. filtrationThe precipitated solid was collected by filtration
  2. washwashed with water
  3. customdried

出典と根拠

ORDレコード
ord-be59f09646f74561bfbbe1178d4f0783
出典データセット
uspto-grants-2013_09
特許番号
US08524744B2

関連ノート

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