Acetone → 4-(3-Methoxy-4-ethoxyphenyl)-3-buten-2-one

HRID 38668

反応式

HRID 38668 の反応式
[OH-].[Na+].[CH3:3][O:4][C:5]1[CH:6]=[C:7]([CH:10]=[CH:11][C:12]=1[O:13][CH2:14][CH3:15])[CH:8]=O.Cl.[CH3:17][C:18]([CH3:20])=[O:19]>C(O)C.O>[CH3:3][O:4][C:5]1[CH:6]=[C:7]([CH:8]=[CH:17][C:18](=[O:19])[CH3:20])[CH:10]=[CH:11][C:12]=1[O:13][CH2:14][CH3:15]

参加物

7

反応物 4

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 671164-Ethoxy-3-methoxybenzaldehyde

生成物 1

HCID 692481204-(3-Methoxy-4-ethoxyphenyl)-3-buten-2-one収率 66.5%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

10% sodium hydroxide aqueous (40 ml) was added under stirring to a solution of 3-methoxy-4-ethoxybenzaldehyde (9.09 g, 50 mmol) in acetone (25 ml), 95% ethanol (25 ml) and water (200 ml). The reaction mixture was stirred for 24 hr at room temperature, after the reaction completed, the reaction mixture was neutralized with 6N hydrochloric acid to adjust pH=7.0. The precipitated solid was collected by filtrating and washed with water and ethanol successively, dried, and then recrystallized from 95% ethanol to give 7.38 g of a pale yellow solid, mp: 95-97° C., yield: 66.5%.

後処理

  1. customThe precipitated solid was collected
  2. filtrationby filtrating
  3. washwashed with water and ethanol successively
  4. customdried
  5. customrecrystallized from 95% ethanol

出典と根拠

ORDレコード
ord-494e067128284a1eb05853ce0472705c
出典データセット
uspto-grants-2013_09
特許番号
US08524744B2

関連ノート

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