Acetone → 4-(3-Oxobutenyl)-benzonitrile
反応式
[OH-].[Na+].[C:3]([C:5]1[CH:12]=[CH:11][C:8]([CH:9]=O)=[CH:7][CH:6]=1)#[N:4].Cl.[CH3:14][C:15]([CH3:17])=[O:16]>O>[C:3]([C:5]1[CH:12]=[CH:11][C:8]([CH:9]=[CH:14][C:15](=[O:16])[CH3:17])=[CH:7][CH:6]=1)#[N:4]参加物
6
反応条件
- 温度
- 14 °C
実験手順
Water (150 ml) and 10% NaOH aqueous solution (4.5 ml) were added under vigorous stirring to a solution of 4-cyanobenzaldehyde (7.0 g, 80.6 mmol) in acetone (40 ml) and water(25 ml). The reaction mixture was stirred at 14° C. for 8 hr, after the reaction completed, the reaction mixture was neutralized with 6N hydrochloric acid to adjust pH=7-8.The precipitated separated solid was collected by filtration and dried, then recrystallized from anhydrous ethanol to give 4.8 g of crystals in needles, mp: 102-103° C., yield: 49.25%.
後処理
- customThe precipitated separated solid
- filtrationwas collected by filtration
- customdried
- customrecrystallized from anhydrous ethanol
出典と根拠
- ORDレコード
- ord-ecc8e11949d745ed975edc16bd2e9197
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08524744B2
反応ノート
読み込み中…