m-Chloroperbenzoic acid → (2'-Benzenesulfinylmethyl-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid

HRID 38695ノート

反応式

HRID 38695 の反応式
[CH3:1][O:2][C:3]1[C:8]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][C:10]=2[CH2:19][S:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[CH:7][C:6]([CH2:27][C:28]([OH:30])=[O:29])=[CH:5][CH:4]=1.ClC1C=C(C=CC=1)C(OO)=[O:36]>ClCl>[C:21]1([S:20]([CH2:19][C:10]2[CH:11]=[C:12]([C:15]([F:18])([F:16])[F:17])[CH:13]=[CH:14][C:9]=2[C:8]2[C:3]([O:2][CH3:1])=[CH:4][CH:5]=[C:6]([CH2:27][C:28]([OH:30])=[O:29])[CH:7]=2)=[O:36])[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

参加物

4

反応物 2

HCID 70297m-Chloroperbenzoic acidHCID 45136825(6-Methoxy-2'-phenylsulfanylmethyl-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid

生成物 1

HCID 45280348(2'-Benzenesulfinylmethyl-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid

試薬・触媒・溶媒 1

HCID 24526Chlorine溶媒

実験手順

To (6-methoxy-2′-phenylsulfanylmethyl-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid (0.030 g, 0.07 mmol) in CH2 Cl2 was added 3-chloroperoxybenzoic acid (0.015 g, 0.07 mmol), and the reaction was stirred at room temperature for 20 minutes. The mixture was concentrated, and the residue was purified by preparative HPLC to give the title compound.

後処理

  1. concentrationThe mixture was concentrated
  2. customthe residue was purified by preparative HPLC

出典と根拠

ORDレコード
ord-6bf1aaa5092049619ee7e417e4db224b
出典データセット
uspto-grants-2013_09
特許番号
US08524748B2

反応ノート

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