反応式
[C:1]1([N:7]2[C:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:10][C:9]([CH2:18][CH2:19][CH:20]=O)=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:22][CH:23]1[CH2:28][NH:27][CH2:26][CH2:25][N:24]1[C:29]1[CH:30]=[C:31]([CH3:35])[CH:32]=[CH:33][CH:34]=1.CCN(C(C)C)C(C)C.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+]>>[CH3:22][CH:23]1[CH2:28][N:27]([CH2:20][CH2:19][CH2:18][C:9]2[CH:10]=[C:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[N:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[N:8]=2)[CH2:26][CH2:25][N:24]1[C:29]1[CH:30]=[C:31]([CH3:35])[CH:32]=[CH:33][CH:34]=1参加物
5
実験手順
107 mg (66%) of target compound was obtained by using a method same as in Example 1 by using 3-(1,5-diphenyl-1H-pyrazol-3-yl)propanal (110 mg, 0.398 mmol), 2-methyl-1-m-tolylpiperazine (69 mg, 0.362 mmol), DIPEA (0.063 mL, 0.362 mmol) and NaBH(OAc)3 (269 mg, 1.267 mmol).
後処理
- custom107 mg (66%) of target compound was obtained
出典と根拠
- ORDレコード
- ord-05acccd8bea44f3ab133b33383f3fdde
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08372844B2
関連ノート
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