Methyl morpholine oxide → 2-Bromo-5-(trifluoromethyl)benzaldehyde

HRID 38702

反応式

HRID 38702 の反応式
[Br:1][C:2]1[CH:9]=[CH:8][C:7]([C:10]([F:13])([F:12])[F:11])=[CH:6][C:3]=1[CH2:4][OH:5].C[N+]1([O-])CCOCC1>C(Cl)Cl.CC#N.[Ru]([O-])(=O)(=O)=O.C([N+](CCC)(CCC)CCC)CC>[Br:1][C:2]1[CH:9]=[CH:8][C:7]([C:10]([F:11])([F:12])[F:13])=[CH:6][C:3]=1[CH:4]=[O:5]

参加物

6

反応物 2

HCID 82029Methyl morpholine oxideHCID 27562482-Bromo-5-(trifluoromethyl)benzyl alcohol

生成物 1

HCID 70180472-Bromo-5-(trifluoromethyl)benzaldehyde

試薬・触媒・溶媒 3

HCID 178419074HCID 178419074、化合物触媒HCID 6342Acetonitrile溶媒HCID 6344Dichloromethane溶媒

実験手順

2-Bromo-5-(trifluoromethyl)benzyl alcohol (2.216 g, 8.69 mmol) and N-methylmorpholine-N-oxide (2.051 g, 17.38 mmol) were combined in CH2Cl2 (44 mL) and MeCN (2.2 mL). Tetrapropylammonium perruthenate (0.311 g, 0.87 mmol) was added, and the reaction was stirred for 20 minutes at room temperature. Once no starting material was seen by analytical tlc, the mixture was concentrated, and the residue was purified by silica gel chromatography to give the title compound.

後処理

  1. concentrationthe mixture was concentrated
  2. customthe residue was purified by silica gel chromatography

出典と根拠

ORDレコード
ord-3b24e4b4e1b945c3aacdfacc4a0d6bd9
出典データセット
uspto-grants-2013_09
特許番号
US08524748B2

関連ノート

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