Azetidine → 1-[(5-Bromo-2-thienyl)methyl]azetidine

HRID 387381ノート

反応式

HRID 387381 の反応式
[Br:1][C:2]1[S:6][C:5]([CH2:7][N:8]2[CH2:12][CH2:11][CH2:10]C2)=[CH:4][CH:3]=1.N1CCC1>>[Br:1][C:2]1[S:6][C:5]([CH2:7][N:8]2[CH2:12][CH2:11][CH2:10]2)=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 10422AzetidineHCID 593327581-[(5-Bromo-2-thienyl)methyl]pyrrolidine

生成物 1

HCID 593327501-[(5-Bromo-2-thienyl)methyl]azetidine

実験手順

The above procedure to make 1-[(5-bromo-2-thienyl)methyl]pyrrolidine was repeated except using azetidine (86 mg, 1.5 mmol) as the amine. Following the purification with the SCX column as described -[(5-bromo-2-thienyl)methyl]pyrrolidine an additional purification step on a 40 g ISCO silica column was necessary to afford the title compound (166 mg) of acceptable purity for use in the next reaction.

後処理

  1. customthe purification with the SCX column
  2. customan additional purification step on a 40 g ISCO silica column

出典と根拠

ORDレコード
ord-23eca20410af448b92c0fb964823589f
出典データセット
uspto-grants-2013_02
特許番号
US08372875B2

反応ノート

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