Calcium Carbonate → strontium bis((2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2H-furan-3-olate)

HRID 387422

反応式

HRID 387422 の反応式
[O:1]=[C:2]1[O:8][C@H:7]([C@H:9]([CH2:11][OH:12])[OH:10])[C:5]([O-:6])=[C:3]1[OH:4].[Sr:13].[Ca].[O:15]=[C:16]1[O:22][C@H:21]([C@H:23]([CH2:25][OH:26])[OH:24])[C:19]([OH:20])=[C:17]1[OH:18].C(=O)([O-])[O-].[Sr+2].C(=O)([O-])[O-].[Ca+2]>O>[O:1]=[C:2]1[O:8][C@H:7]([C@H:9]([CH2:11][OH:12])[OH:10])[C:5]([O-:6])=[C:3]1[OH:4].[Sr+2:13].[O:15]=[C:16]1[O:22][C@H:21]([C@H:23]([CH2:25][OH:26])[OH:24])[C:19]([O-:20])=[C:17]1[OH:18]

参加物

8

反応物 6

HCID 10112Calcium CarbonateHCID 15407Strontium carbonateHCID 5359327StrontiumHCID 5460341CalciumHCID 54670067L-Ascorbic Acid3 回HCID 178519208HCID 178519208、化合物

生成物 1

HCID 140483007strontium bis((2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2H-furan-3-olate)

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

The following reaction is carried out to form a strontium (M) ascorbate salt using ascorbate, strontium and calcium where the Sr:Ca mole ratio is 0.6 moles Sr:0.4 moles Ca. Ascorbic acid is dissolved in distilled H20 at 90° C. in an appropriate reaction vessel (Meuller). The water mass is 10-25% of the mass of ascorbic acid. As soon as the ascorbic acid is dissolved, slowly add strontium carbonate followed by calcium carbonate. Keep temperature constant. As the reaction proceeds, add 0.5-5% water by mass. Reduce temperature to 60° C. 10 minutes after the last of the mineral salt is added. The resulting slurry is transferred to trays and placed in the oven at 60° C. until dry. Optionally, the strontium ascorbate (M) salt may need to be turned over once as part of the drying process. The dry strontium ascorbate (M) salt mass can be milled to varying particle sizes including a fine powder or a granular powder for use in various oral dosage forms.

後処理

  1. customto 60° C
  2. addition10 minutes after the last of the mineral salt is added
  3. customplaced in the oven at 60° C.
  4. customuntil dry
  5. customThe dry strontium ascorbate (M) salt mass can be milled

出典と根拠

ORDレコード
ord-e1d0bca1fe794176b64b1c5e9d484886
出典データセット
uspto-grants-2013_02
特許番号
US08372992B2

関連ノート

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