Methyl iodide → 1-[4-chloro-3-(trifluoromethyl)phenyl]-S-methylisothiourea hydroiodide
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH2:11])=[S:10])=[CH:4][C:3]=1[C:12]([F:15])([F:14])[F:13].[CH3:16][I:17]>CO>[IH:17].[CH3:16][S:10][C:9](=[NH:11])[NH:8][C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([C:12]([F:15])([F:13])[F:14])[CH:4]=1参加物
4
実験手順
4-Chloro-3-trifluoromethyl-phenylthiourea (5.0 g, 19.63 mmol) was dissolved in ca. 80 mL of anhydrous MeOH and methyl iodide (2.93 g, 20.61 mmol) was added via a syringe. The reaction mixture was refluxed for 12 hours. Then it was cooled down to ambient temperature and solvent was removed in vacuo to give colorless oil (7.85 g), which was taken to the next step without further purifications.
後処理
- temperatureThe reaction mixture was refluxed for 12 hours
- customsolvent was removed in vacuo
出典と根拠
- ORDレコード
- ord-1f9659046d19427a899901f7e2b09927
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08372971B2
反応ノート
読み込み中…