Acetic Acid → 8-(2-Methoxy-4-aminocarbonyl-phenyl)-1H,3H-purin-2,6-dione

HRID 3877ノート

反応式

HRID 3877 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9](O)=[O:10])[CH:6]=[CH:5][C:4]=1[C:12]1[NH:20][C:19]2[C:18](=[O:21])[NH:17][C:16](=[O:22])[NH:15][C:14]=2[N:13]=1.[NH3:23].O.C(O)(=O)C>S(Cl)(Cl)=O.CN(C)C=O>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]([NH2:23])=[O:10])[CH:6]=[CH:5][C:4]=1[C:12]1[NH:20][C:19]2[C:18](=[O:21])[NH:17][C:16](=[O:22])[NH:15][C:14]=2[N:13]=1

参加物

8

反応物 4

HCID 176Acetic AcidHCID 222AmmoniaHCID 962WaterHCID 13532361HCID 13532361、化合物

生成物 1

HCID 201532438-(2-Methoxy-4-aminocarbonyl-phenyl)-1H,3H-purin-2,6-dione

試薬・触媒・溶媒 3

HCID 6228Dimethylformamide触媒HCID 6228Dimethylformamide溶媒2 回HCID 24386Thionyl Chloride溶媒2 回

実験手順

A quantity of 2.3 gm of 8-(2-methoxy-4-carboxy-phenyl)-1H,-3H-purin-2,6-dione are refluxed for one hour in 50 ml of thionyl chloride with the addition of 1 drop of dimethylformamide. The excess thionyl chloride is drawn off, and the residue is stirred for 16 hours at ambient temperature with a solution of ammonia in dimethylformamide. The dimethylformamide is drawn off, the remainder is mixed with water and acidified with glacial acetic acid, and the product precipitated is filtered off.

後処理

  1. customthe product precipitated
  2. filtrationis filtered off

出典と根拠

ORDレコード
ord-6a823073ab7c4f51901f88aec89eb947
出典データセット
uspto-grants-1988_02
特許番号
US04722929

反応ノート

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