4-Fluorophenyl isocyanate → N1-[5-({7-[3-(Dimethylamino)propoxy]-6-methoxy-4-quinolyl}sulfanyl)-2-thienyl]-N'-(4-fluorophenyl)urea
反応式
[CH2:1]([N:3]([CH2:27]C)[CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:17]=[C:16]2[C:11]([C:12]([S:18][C:19]3[S:23][C:22]([NH2:24])=[CH:21][CH:20]=3)=[CH:13][CH:14]=[N:15]2)=[CH:10][C:9]=1[O:25][CH3:26])C.[F:29][C:30]1[CH:35]=[CH:34][C:33]([N:36]=[C:37]=[O:38])=[CH:32][CH:31]=1>O1CCCC1>[CH3:27][N:3]([CH3:1])[CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:17]=[C:16]2[C:11]([C:12]([S:18][C:19]3[S:23][C:22]([NH:24][C:37]([NH:36][C:33]4[CH:34]=[CH:35][C:30]([F:29])=[CH:31][CH:32]=4)=[O:38])=[CH:21][CH:20]=3)=[CH:13][CH:14]=[N:15]2)=[CH:10][C:9]=1[O:25][CH3:26]参加物
4
実験手順
5-({7-[3-(Diethylamino)propoxy]-6-methoxy-4-quinolyl}sulfanyl)-2-thiophenylamine (190 mg), parafluorophenyl isocyanate (69 mg) and tetrahydrofuran (30 ml) were stirred together at room temperature for 30 minutes. The organic solvent was distilled off under reduced pressure, and the residue was purified by column chromatography (ethyl acetate, followed by ethyl acetate:methanol=10:1) using NH type silica gel. The solvent was distilled off under reduced pressure, and ethyl acetate was added to the residue for solidification to obtain 16 mg of a yellowish-brown solid.
後処理
- distillationThe organic solvent was distilled off under reduced pressure
- customthe residue was purified by column chromatography (ethyl acetate, followed by ethyl acetate:methanol=10:1)
- distillationThe solvent was distilled off under reduced pressure, and ethyl acetate
- additionwas added to the residue for solidification
出典と根拠
- ORDレコード
- ord-37967c42f7a34e688b8c9150ac24bbb8
- 出典データセット
- uspto-grants-2013_02
- 特許番号
- US08372981B2
反応ノート
読み込み中…