Dimethylformamide → (Tetrahydro-2H-pyran-4-yl)acetyl chloride

HRID 38787

反応式

HRID 38787 の反応式
[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([OH:10])=O)[CH2:3][CH2:2]1.CN(C)C=O.C(Cl)(=O)C([Cl:19])=O>ClCCl>[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([Cl:19])=[O:10])[CH2:3][CH2:2]1

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 2773575Tetrahydropyran-4-ylacetic acid

生成物 1

HCID 24229747(Tetrahydro-2H-pyran-4-yl)acetyl chloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a mixture of tetrahydro-2H-pyran-4-ylacetic acid (89 mg), N,N-dimethyl formamide (1 μL), and dichloromethane (1 mL) was added oxalylchloride (54 μL), and the mixture was stirred at room temperature for 2 hours. The reaction liquid was concentrated under reduced pressure, and then toluene (1 mL) was added thereto, followed by further concentration under reduced pressure, to obtain crude tetrahydro-2H-pyran-4-yl acetyl chloride.

後処理

  1. customThe reaction liquid
  2. concentrationwas concentrated under reduced pressure
  3. additiontoluene (1 mL) was added
  4. concentrationfollowed by further concentration under reduced pressure

出典と根拠

ORDレコード
ord-555ce1cf5e494e17afab4008bd8bce25
出典データセット
uspto-grants-2013_09
特許番号
US08524727B2

関連ノート

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