Ethanol → HCID 24985023、化合物

HRID 388131ノート

反応式

HRID 388131 の反応式
[C:1]1([C@H:7]([NH:9][C:10]2[C:15]([N+:16]([O-])=O)=CN=[C:12]([C:19]3[CH:28]=[CH:27][CH:26]=[C:25]4[C:20]=3[CH:21]=[CH:22][CH:23]=[N:24]4)[CH:11]=2)[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1([C@H](NC2C=C(C3C=CC=C4C=3C=CC=N4)N=C[C:39]=2[NH2:54])C)C=CC=CC=1.[H][H].[CH2:57]([OH:59])C>[Pd]>[C:1]1([C@H:7]([N:9]2[C:10]3[C:15](=[N:54][CH:39]=[C:12]([C:19]4[CH:28]=[CH:27][CH:26]=[C:25]5[C:20]=4[CH:21]=[CH:22][CH:23]=[N:24]5)[CH:11]=3)[NH:16][C:57]2=[O:59])[CH3:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

5

反応物 3

HCID 702EthanolHCID 86626409HCID 86626409、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 24985023HCID 24985023、化合物収率 97.9%

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

((1R)-1-phenylethyl)(3-amino-6-(5-quinolyl)(4-pyridyl))amine ((1R)-1-Phenylethyl)(5-nitro-2-(5-quinolyl)(4-pyridyl))amine (500 mg, 1.35 mmol) was dissolved in ethanol (100 mL). Palladium on carbon (70 mg) was added followed by a hydrogen balloon. The reaction was stirred at room temperature for 18 h, then filtered through celite. The filtrate was condensed under reduced pressure to afford the desired product (450 mg, 97.9%). (MS (ESI) m/z 341 [M+1]+.

後処理

  1. filtrationfiltered through celite
  2. customcondensed under reduced pressure

出典と根拠

ORDレコード
ord-ebef9d952b684c2ca9414dd62f5fef6f
出典データセット
uspto-grants-2013_02
特許番号
US08372976B2

反応ノート

読み込み中…